Alpha thalassemia affects the amount of hemoglobin in the red blood cells. The elevated Hgb A2 and Hgb F suggest beta-thalassemia trait. Beta Thalassemia Trait/Minor. In this form of beta thalassemia, two defective genes are passed to the child and the child has no normal beta.chain gene. The diagnosis of beta thalassemia minor is made if the HbA 2 level is more than 3.5%. It causes an increase in minor hemoglobin components. Persons with beta thalassemia major are diagnosed during infancy. People with beta-thalassemia major often have larger percentages of Hgb F. That is because beta-thalassemia affects the balance of alpha and beta hemoglobin chain formation greatly. Thalassemia Intermedia Thalassemia Major or Cooley’s Anemia. He is termed as homozygous for beta thalassemia. Evaluation: Forms of disease diagnosed through gel-electrophoresis of globin chains; Unexplained finding is that although there is a decrease in the Hgb concentration and MCV, there is a normal or slightly increased RBC count ; Ratio used: Mentzer Ratio = MCV / RBC. Alpha thalassemia, which is characterized by genetic defects in the alpha-globin gene, is another known cause of mild microcytic anemia and has features similar to those of beta thalassemia. Genetics – (see "Introduction to hemoglobin mutations" and "Molecular genetics of the thalassemia syndromes") The alpha globin one-gene deletion is consistent with alpha thalassemia silent carrier. Thalassemia is an inherited blood disorder that is passed down through the parent’s genes. Beta thalassemia minor is a common condition which is symptomless most of the time. 3. Thalassemia can cause mild or severe anemia. Pallor, irritability, growth retardation, abdominal swelling, and jaundice appear during the sec- Thalassemia is a common cause of anemia, especially microcytic anemia. Marion A. Koerper, MD UCSF School of Medicine San Francisco, CA. There are also terms for how serious the thalassemia is. There is the deficiency of beta globin production in the body which leads to significant illness. if it is less than 13 it is highly predictive of thalassemia; greater than 13 indicates an iron deficiency or anemia of inflammation The diagnosis of beta thalassemia minor is made if the HbA 2 level is more than 3.5%. Beta Thalassemia Trait/Minor Beta thalassemia minor is a common condition which is symptomless most of the time. Adult hemoglobin (hemoglobin A) is made of alpha and beta globins. Although the features are similar to those of alpha thalassemia, beta thalassemia is more severe than its counterpart. Alpha thalassemia is common in people of African, Southern Chinese, Southeast Asian, Middle Eastern and Mediterranean descent. with alpha thalassemia trait. Although the features are similar to those of alpha thalassemia, beta thalassemia is more severe than its counterpart. There are two main types of thalassemia: alpha and beta. The child is probably an alpha + beta thalassemia carrier. Thalassemia Intermedia The two types are alpha thalassemia and beta thalassemia. Learn how to distinguish alpha thalassemia and beta thalassemia. The pathogenesis and treatment of alpha and beta thalassemia, including the role of hematopoietic cell transplantation (HCT), monitoring of iron stores, and iron chelation, are discussed in detail separately. The terms alpha and beta refer to the part of the hemoglobin the person is lacking. So this child has alpha thalassemia silent carrier/beta thalassemia minor. 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